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Apart from sheer overindulgence, the primary cause of a hangover is
dehydration, according to Dr. Petros Levounis, director of the Addiction
Institute of New York at St. Luke's-Roosevelt Hospital Center. Alcohols and the
sugars they contain deplete fluids from the body and the brain – a key reason
for headaches, dry mouth, upset stomachs and overall malaise. "Water performs a
lot of services: it gets you re-hydrated, flushes out your system and helps you
metabolize alcohol faster,” says Dr. Marc Siegel, a clinical associate professor
of medicine, New York University School of Medicine.

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